XGenomes is a San Francisco-based genomics startup that is developing a new technology for DNA sequencing. The platform combines novel biochemistry, specialized hardware, and proprietary algorithms to sequence unadulterated single molecules of DNA directly, eliminating the need for library preparation.
XGenomes was founded by the XGenomes Team. The venture is currently at the launched stage and has been featured as part of the Y Combinator startup ecosystem.
XGenomes achieves high accuracy through several layers of in-built redundancy, including the concurrent sequencing of both strands of the double-helix. This allows the technology to capture complete genomic data, including structural variants, single nucleotide variants, long-range haplotype phase, and repetitive genomic 'dark matter'.
XGenomes aims to achieve a cost of goods for consumables at less than $10 per sequence. The company plans to price its product to grow the market while maintaining a margin of over 90%, starting with a service-based model for high-value customers before moving to selling instruments and consumables.
XGenomes eliminates the bioinformatics bottleneck by streamlining the sequencing process so that DNA extraction is integrated directly with sequencing. Because the platform sequences unadulterated single molecules without library preparation, the data generated is more direct and less computationally intensive to process than traditional methods.
XGenomes is based in San Francisco, California. The company operates as a full-time venture and maintains a remote-friendly work environment.